Oligomeric Proanthocyanidins (OPCs)

OPC-3® Original Research Articles/ References

A recent study, e-published in Phytotherapy Research, evaluates how quickly Isotonix OPC-3® is absorbed vs. the same formulation in tablet form (not commercially available.)

A group of European researchers examined, over a four hour period, the ability of Isotonix OPC-3 to act as an antioxidant by measuring oxygen free radicals in the blood of human subjects.

Isotonix OPC-3 reduced plasma oxygen free radicals (working as an effective antioxidant) within 10 minutes. The OPC-3® tablet took about 1 hour to produce a similar effect. Furthermore, the investigators noted that Isotonix OPC-3 had a stronger antioxidant effect throughout the entire 4 hour period vs. OPC-3 in tablet form.*
The authors concluded: “the findings demonstrate that the flavonoid mixture provided in isotonic OPC-3 is significantly more bioavailable in humans, in terms of antioxidant activity than an equivalent mixture in tablet form. Furthermore, the isotonic OPC-3 formulation resulted in a stronger antioxidative effect than an equivalent mixture in tablet form.*

Accelerated Antioxidant Bioavailability of OPC-3 Bioflavonoids Administered as Isotonic Solution. Cesarone MR, Grossi MG, Di Renzo A, Errichi S, Schönlau F, Wilmer JL, Lange M, Blumenfeld J. Phytother Res. 2009 Jun;23(6):775-7.

To view the abstract, click on:

Improvement in Circulation and in Cardiovascular Risk Factors with a Proprietary Isotonic Bioflavonoid Formula OPC-3.

Cesarone MR, DiRenzo A, Errichi S, Schonlau F, Wilmer JL, Blumenfeld, J. Department of Biomedical Science, G D‘Annunzio University Chieti, Pescara, Italy. Angiology 2008 Aug-Sep; 59(4):408-14.

To view the abstract and access the article, click on: